Scientific Publications

Productive Replication of Ebola Virus is Regulated By the c-Abl1 Tyrosine Kinase

García M, Cooper A, Shi W, Bornmann W, Carrion R, Kalman D, Nabel GJ. (2012) Productive replication of Ebola virus is regulated by the c-Abl1 tyrosine kinase. Sci Transl Med. 4:123ra24.

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Progressive Multifocal Leukoencephalopathy (PML) Development is Associated with Mutations in JC Virus Capsid Protein VP1 That Change its Receptor Specificity

Gorelik L, Reid C, Testa M, Brickelmaier M, Bossolasco S, Pazzi A, Bestetti A, Carmillo P, Wilson E, McAuliffe M, Tonkin C, Carulli JP, Lugovskoy A, Lazzarin A, Sunyaev S, Simon K, Cinque P. (2011) Progressive multifocal leukoencephalopathy (PML) development is associated with mutations in JC virus capsid protein VP1 that change its receptor specificity.  J Infect Dis. Jul 1;204(1):103-14.

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c-Abl in Neurodegenerative Disease

Schlatterer SD, Acker CM, Davies P. (2011) c-Abl in neurodegenerative disease. J Mol Neurosci. 45:445-52.

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Novel Regulation of Parkin Function Through c-Abl-mediated Tyrosine Phosphorylation: Implications for Parkinson’s Disease

Imam SZ, Zhou Q, Yamamoto A, Valente AJ, Ali SF, Bains M, Roberts JL, Kahle PJ, Clark RA, Li S. (2011) Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: implications for Parkinson’s disease. J Neurosci. 31:157-63.

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Variola and Monkeypox Viruses Utilize Conserved Mechanisms of Virion Motility and Release that Depend on Abl and SRC Family Tyrosine Kinases

Reeves PM, Smith SK, Olson VA, Thorne SH, Bornmann W, Damon IK, Kalman D. (2011) Variola and monkeypox viruses utilize conserved mechanisms of virion motility and release that depend on abl and SRC family tyrosine kinases. J Virol. 85(1):21-31.

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Phosphorylation By the c-Abl Protein Tyrosine Kinase Inhibits Parkin’s Ubiquitination and Protective Function

Ko HS, Lee Y, Shin JH, Karuppagounder SS, Gadad BS, Koleske AJ, Pletnikova O, Troncoso JC, Dawson VL, Dawson TM. (2010) Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin’s ubiquitination and protective function. Proc Natl Acad Sci U S A. 107:16691-6.

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Abl Family Tyrosine Kinases Regulate Sialylated Ganglioside Receptors for Polyomavirus

Swimm AI, Bornmann W, Jiang M, Imperiale MJ, Lukacher AE, Kalman D (2010) Abl family tyrosine kinases regulate sialylated ganglioside receptors for polyomavirus. J. Virol. 84, 4243-4251.

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Human polyoma viruses and disease with emphasis on clinical BK and JC.

Gorelik L, Reid C, Testa M, Brickelmaier M, Bossolasco S, Pazzi A, Bestetti A, Carmillo P, Wilson E, McAuliffe M, Tonkin C, Carulli JP, Lugovskoy A, Lazzarin A, Sunyaev S, Simon K, Cinque P. (2011) Boothpur R and Brennan D. C. (2010) Human polyoma viruses and disease with emphasis on clinical BK and JC. J. Clin. Virol. Doi 10.1416/j.jcv.2009.12.006

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Aligning Antimicrobial Drug Discovery with Complex and Redundant Host-pathogen Interactions

Lebeis SL, Kalman D. (2009) Aligning antimicrobial drug discovery with complex and redundant host-pathogen interactions. Cell Host Microbe 5:114-22.

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Molecular Pathways of Neurodegeneration in Parkinson’s Disease

Dawson TM, Dawson VL. Molecular pathways of neurodegeneration in Parkinson’s disease. (2003) Science. 302:819-22.

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