Scientific Publications

Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3

Mao X, Ou MT, Karuppagounder SS, Kam TI, Yin X, Xiong Y, Ge P, Umanah GE, Brahmachari S, Shin JH, Kang HC, Zhang J, Xu J, Chen R, Park H, Andrabi SA, Kang SU, Gonçalves RA, Liang Y, Zhang S, Qi C, Lam S, Keiler JA, Tyson J, Kim D, Panicker N, Yun SP, Workman CJ, Vignali DA, Dawson VL, Ko HS, Dawson TM. (2016) Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3. Science. Sep 30;353(6307). pii: aah3374.

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Pathological α-synuclein Transmission Initiated by Binding Lymphocyte-activation Gene 3

Mao, M. T. Ou, S. S. Karuppagounder, T. I. Kam, X. Yin, Y. Xiong, P. Ge, G. E. Umanah, S. Brahmachari, J. H. Shin, H. C. Kang, J. Zhang, J. Xu, R. Chen, H. Park, S. A. Andrabi, S. U. Kang, R. A. Gonçalves, Y. Liang, S. Zhang, C. Qi, S. Lam, J. A. Keiler, J. Tyson, D. Kim, N. Panicker, S. P. Yun, C. J. Workman, D. A. Vignali, V. L. Dawson, H. S. Ko, T. M. Dawson. (2016) Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3. Science353:aah374.

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Reassessing the Risk of Natalizumab-associated PML

Berger JR, Fox RJ.  (2016) Reassessing the risk of natalizumab-associated PML.  J Neurovirol. 2016 Aug;22(4):533-5.

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Nilotinib – Differentiating the Hope from the Hype

Wyse RK, Brundin P, Sherer TB.  (2016) Nilotinib – Differentiating the Hope from the Hype. J Parkinsons Dis. 2016 Jul 12.

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Nilotinib Effects in Parkinson’s Disease and Dementia with Lewy Bodies

Pagan F, Hebron M, Valadez EH, Tores-Yaghi Y, Huang X, Mills RR, Wilmarth BM, Howard H, Dunn C, Carlson A, Lawler A, Rogers SL, Drew Falconer R, Ahn J, Li Z, Moussa C.  (2016) Nilotinib Effects in Parkinson’s disease and Dementia with Lewy bodies.  J Parkinsons Dis. 2016 Jul 11.

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Activation of Tyrosine Kinase c-Abl Contributes to α-synuclein-Induced Neurodegeneration

Brahmachari S, Ge P, Lee SH, Kim D, Karuppagounder SS, Kumar M, Mao X, Shin JH, Lee Y, Pletnikova O, Troncoso JC, Dawson VL, Dawson TM, Ko HS.  (2016) Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration.  J Clin Invest. 126:2970-88.

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Targeting α-synuclein for Treatment of Parkinson’s Disease: Mechanistic and Therapeutic Considerations

Dehay B, Bourdenx M, Gorry P, Przedborski S, Vila M, Hunot S, Singleton A, Olanow CW, Merchant KM, Bezard E, Petsko GA, Meissner WG. (2015) Targeting α-synuclein for treatment of Parkinson’s disease: mechanistic and therapeutic considerations. Lancet Neurol. 14:855-66.

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New Tricks for Old Dogs: Countering Antibiotic Resistance in Tuberculosis with Host-directed Therapeutics

Hawn TR, Shah JA, Kalman D. (2015) New tricks for old dogs: countering antibiotic resistance in tuberculosis with host-directed therapeutics. Immunol Rev. Mar;264(1):344-62.

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Anti-JC Virus Antibody Levels in Serum or Plasma Further Define Risk of Natalizumab-associated Progressive Multifocal Leukoencephalopathy

Plavina T, Subramanyam M, Bloomgren G, Richman S, Pace A, Lee S, Schlain B, Campagnolo D, Belachew S, Ticho B.  (2014) Anti-JC virus antibody levels in serum or plasma further define risk of natalizumab-associated progressive multifocal leukoencephalopathy.  Ann. Neurol. 76, 802-812.

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c-Abl Phosphorylates Alpha-synuclein and Regulates its Degradation: Implication for Alpha-synuclein Clearance and Contribution to the Pathogenesis of Parkinson’s Disease

Mahul-Mellier AL, Fauvet B, Gysbers A, Dikiy I, Oueslati A, Georgeon S, Lamontanara AJ, Bisquertt A, Eliezer D, Masliah E, Halliday G, Hantschel O, Lashuel HA. (2014) c-Abl phosphorylates alpha-synuclein and regulates its degradation: implication for alpha-synuclein clearance and contribution to the pathogenesis of Parkinson’s disease. Hum Mol Genet. 23:2858-79.

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