
About Progressive Multifocal Leukoencephalopathy
PML is a rare disease that causes rapidly fatal brain infection. It occurs as a side effect of some medications used to treat multiple sclerosis and other autoimmune diseases, as well as in patients with HIV and certain cancers of the blood and lymph. PML is caused by a human polyomavirus, the John Cunningham virus (JC virus), which resides in an inactive form in the kidney and bone marrow of more than 60% of adults. PML develops when the inactive form of the JC virus becomes activated in patients due to chronic or drug-induced immune suppression, whereupon the virus migrates into the brain and causes irreversible brain damage, a debilitating loss of cognitive and motor function, and likely death. There is currently no approved treatment for PML.
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Our RAMP™ (Re-engineering Approach with Metabolism Preserved) drug innovation engine enables us to design and develop novel small-molecule product candidates with enhanced potency and preserved safety profile to treat neurodegenerative diseases.
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