About Parkinson’s Disease
Parkinson’s disease develops when neurons that produce the neurotransmitter dopamine begin to die or lose function. Loss of these and other neurons leads to involuntary tremors, slow and imprecise movements, muscle stiffness, postural instability, loss of memory and dysfunction of the GI tract. All marketed therapeutic approaches to treat Parkinson’s help manage the symptoms of the disease, but there are currently no available treatments to slow or stop the disease’s relentless progression.
The underlying causes of neural death in Parkinson’s disease are beginning to be understood. Abl kinases have been shown to play a critical role in monitoring insults to neurons inside and outside of the brain and regulating biochemical pathways that are responsible for protecting neurons from dying or losing function in the brain and other areas of the body. In addition, recent research has demonstrated that Abl kinases are essential checkpoint regulators that play a central role in Parkinson’s disease progression.
RAMP™ Drug Innovation Engine
Our RAMP™ (Re-engineering Approach with Metabolism Preserved) drug innovation engine enables us to design and develop novel small-molecule product candidates with enhanced potency and preserved safety profile to treat neurodegenerative diseases.
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