Annual report pursuant to Section 13 and 15(d)

Commitments and Contingencies - Additional Information (Details)

v3.22.1
Commitments and Contingencies - Additional Information (Details)
1 Months Ended 12 Months Ended
Mar. 31, 2022
USD ($)
shares
Aug. 01, 2018
USD ($)
Apr. 01, 2014
USD ($)
$ / shares
shares
Jun. 18, 2010
USD ($)
shares
Jun. 08, 2010
USD ($)
Agreements
shares
Apr. 30, 2018
USD ($)
Dec. 31, 2021
USD ($)
Dec. 31, 2020
USD ($)
$ / shares
shares
Dec. 31, 2019
shares
Jun. 30, 2018
Loss Contingencies [Line Items]                    
Operating lease, term of contract                   1 year
Lease obligation   $ 54,000                
Operating leases description             The total lease obligation was $54,000, payable in 12 equal monthly installments commencing August 1, 2018. Since the end of the one-year initial term on July 31, 2019, the lease continues on a month-to-month basis.      
Lease obligation payable monthly installments   12 equal monthly installments                
Total potential milestone payments             $ 5,625,000      
2020 CEO Agreement                    
Loss Contingencies [Line Items]                    
Annual base salary               $ 455,000    
Percentage of annual base salary               35.00%    
Stock option granted | shares               100,000    
Stock option granted, vesting period               3 years    
Stock option granted, exercise price | $ / shares               $ 10.00    
Increase in target bonus, percentage               35.00%    
2014 CEO Agreement                    
Loss Contingencies [Line Items]                    
Annual base salary     $ 224,000         $ 292,800    
Stock option granted | shares     43,708         21,854 196,685  
Stock option granted, vesting period     10 years         12 months    
Stock option granted, exercise price | $ / shares     $ 0.38              
2018 Flagship Agreement                    
Loss Contingencies [Line Items]                    
Consulting services fee per month           $ 12,500        
Consulting services fee accrued           $ 12,500        
Agreement ended date description           The 2018 Flagship Agreement ended on December 31, 2020 and the Frattaroli Employment Agreement superseded the 2018 Flagship Agreement in all respects on January 1, 2021.        
Emory University License Agreements                    
Loss Contingencies [Line Items]                    
License agreements, fair value of shares issued         $ 313,500          
Number of license agreements | Agreements         2          
License agreement description         the License A term is the later of 10 years or until the expiration of the patent rights. License B was terminated in May 2013 under the normal course of business.          
Total potential milestone payments         $ 280,000   0 $ 0    
Emory University License Agreements | License A [Member]                    
Loss Contingencies [Line Items]                    
License agreements, shares issued | shares         393,370          
License agreement, term         10 years          
Emory University License Agreements | License B [Member]                    
Loss Contingencies [Line Items]                    
License agreements, fair value of shares issued         $ 437,078          
Duke University License Agreement                    
Loss Contingencies [Line Items]                    
License agreements, shares issued | shares       611,909            
License agreements, fair value of shares issued       $ 247,500            
License agreement, term       10 years            
Total potential milestone payments       $ 280,000     0 0    
License termination date       April 16, 2020            
License termination cost       $ 0            
Sphaera Agreement                    
Loss Contingencies [Line Items]                    
License agreement, fixed fee paid             $ 160,000      
Frattaroli Employment Agreement                    
Loss Contingencies [Line Items]                    
Annual base salary               $ 375,000    
Percentage of annual base salary               30.00%    
Stock option granted | shares               100,000    
Stock option granted, vesting period               3 years    
Stock option granted, exercise price | $ / shares               $ 10.00    
Increase in target bonus, percentage               30.00%    
Subsequent Event [Member] | 2020 CEO Agreement                    
Loss Contingencies [Line Items]                    
Annual base salary $ 510,000                  
Percentage of annual base salary 50.00%                  
Stock option granted | shares 125,000                  
Stock option granted, vesting period 3 years                  
Increase in target bonus, percentage 50.00%                  
Subsequent Event [Member] | 2020 CFO Agreement                    
Loss Contingencies [Line Items]                    
Annual base salary $ 400,000                  
Percentage of annual base salary 40.00%                  
Stock option granted | shares 62,500                  
Stock option granted, vesting period 3 years                  
Increase in target bonus, percentage 40.00%                  
Subsequent Event [Member] | Frattaroli Employment Agreement                    
Loss Contingencies [Line Items]                    
Annual base salary $ 400,000                  
Percentage of annual base salary 40.00%                  
Increase in target bonus, percentage 40.00%